{"product_id":"pnc-27-10mg","title":"PNC-27 - 10MG","description":"\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003ePNC-27\u003c\/strong\u003e\u003c\/span\u003e is an experimental anticancer peptide being investigated primarily in laboratory and preclinical research. It is not an established or approved cancer treatment.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"text-decoration: underline;\"\u003ePNC-27 \u003c\/span\u003e\u003c\/strong\u003e— Potential Research Benefits\u003c\/p\u003e\n\u003cp\u003eSelective targeting of cancer cells: Research suggests PNC-27 may preferentially target certain cancer cells while having substantially less effect on normal cells studied.\u003cbr\u003eCancer-cell membrane disruption: PNC-27 interacts with HDM2\/MDM2 proteins expressed on the surface of certain cancer cells and appears to form pores in the cell membrane, potentially causing rapid cell destruction.\u003cbr\u003eUnique mechanism of action: Rather than depending primarily on traditional programmed cell death (apoptosis), PNC-27 appears capable of causing membrane lysis and necrotic cell death.\u003cbr\u003ePotential activity despite abnormal p53: Because its proposed mechanism involves membrane-associated HDM2, PNC-27 has shown experimental activity in some cancer models where normal p53 function is absent or impaired.\u003cbr\u003eInvestigated in leukemia: Preclinical research has examined PNC-27 against acute myeloid leukemia (AML) cells, including leukemia-stem-cell-enriched populations.\u003cbr\u003ePotential broad research applications: Since HDM2 can be present on the membranes of different cancer-cell types, researchers have investigated whether PNC-27 could have activity across multiple cancers.\u003c\/p\u003e","brand":"Amino Sciences","offers":[{"title":"Default Title","offer_id":49448027717787,"sku":null,"price":120.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0691\/0433\/7051\/files\/PNC27.png?v=1788501220","url":"https:\/\/aminosciences.net\/products\/pnc-27-10mg","provider":"Amino Sciences","version":"1.0","type":"link"}