FOXO4 10mg

FOXO4- is a research peptide designed to disrupt the interaction between the FOXO4 protein and p53 in senescent cells. It is primarily studied for its senolytic (senescent-cell clearing) properties.

Below are the research-based potential benefits:

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1. Senescent Cell Clearance (Senolytic Effect)
    •    Targets and induces apoptosis in senescent cells
    •    May reduce senescent cell burden in tissues
    •    Studied as a potential anti-aging mechanism

Why it matters:
Senescent cells accumulate with age and contribute to inflammation, tissue dysfunction, and age-related decline.

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2. Reduction in Chronic Inflammation
    •    Senescent cells secrete inflammatory cytokines (SASP – Senescence-Associated Secretory Phenotype)
    •    FOXO4-DRI may lower pro-inflammatory signaling by clearing these cells
    •    Potential improvement in inflammatory-driven aging processes

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3. Tissue Rejuvenation (Preclinical)

Animal studies have suggested:
    •    Improved kidney function in aged mice
    •    Enhanced physical fitness markers
    •    Possible improvement in organ resilience

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4. Cellular Longevity Research
    •    Investigated in anti-aging models
    •    Explored for improving lifespan and healthspan
    •    Studied in relation to DNA damage response and cellular stress resistance

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5. Age-Related Disease Research Applications

Being studied in connection with:
    •    Osteoarthritis
    •    Pulmonary fibrosis
    •    Atherosclerosis
    •    Frailty syndromes
    •    Age-related organ dysfunction

(All currently preclinical research.)

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Mechanism of Action (Simplified)

FOXO4 in senescent cells binds to p53 to prevent apoptosis.
FOXO4-DRI disrupts this interaction → activates p53 → selective death of senescent cells.

(Lyophilized Powder)